TY -的A2 Boheler Kenneth盟——酒鬼,伯纳黛特盟,Sinha Garima盟——Lobba艾琳r . m . AU -希腊,Steven j . AU - Rameshwar Pranela PY - 2013 DA - 2013/12/10 TI -审查干细胞翻译和潜在的混淆的癌症干细胞SP - 241048六世- 2013 AB -间充质干细胞(msc)多功能细胞发现胎儿和成人组织。msc显示承诺等细胞治疗一些疾病与炎症有关。在成人中,msc主要存在于骨髓(BM)和脂肪组织。在BM, msc被发现在低频率周围血管和骨小梁。msc再生医学是有吸引力的候选人考虑到他们在收获和扩张及其独特的能力绕过同种异体的免疫系统主机。此外,msc施加pathotropism迁移到病变区域的能力。尽管msc的“吸引力”的特性,他们翻译的病人需要深入的研究。“现成的”提出了msc用于同种异体的主机。因此,移植msc,放置在一个国外主机,可以接收到提示细胞微环境的转换。使用msc涉及的一个重要问题的能力促进乳腺癌和其他癌症的支持carcinoma-associated成纤维细胞。 MSCs could show distinct effect on each subset of cancer cells. This could lead to untoward effect during MSC therapy since the MSCs would be able to interact with undiagnosed cancer cells, which might be in a dormant state. Based on these arguments, further preclinical research is needed to ensure patient safety with MSC therapy. Here, we discuss the basic biology of MSCs, discuss current applications, and provide evidence why it is important to understand MSC biology in the context of diseased microenvironment for safe application. SN - 1687-966X UR - https://doi.org/10.1155/2013/241048 DO - 10.1155/2013/241048 JF - Stem Cells International PB - Hindawi Publishing Corporation KW - ER -