TY - Jour A2 - Cao，Hongbao Au - Rudko，Olga I. Au - Tretiakov，Artemii V. Au - Naumova，Elena A. Au - Klimov，Eugene A. PY - 2020 DA - 2020/11/30 TI - 作者焦虑进展中的PPAR：文献分析和信号通路重建SP - 8859017 VL - 2020 AB - 过氧化物体增殖物激活受体（PPAR）组包括由PPARG，PPARA和PPART基因编码的三种同种型。在与焦虑发育有关的大脑中，包括高浓度的PPAR，包括海马和Amygdala。在三种PPAR同种型中，PPARG证明了CNS中的最高表达，其中可以在神经元，星形胶质细胞和神经胶质细胞中找到。在此，在杏仁达拉中发生最高的PPARG表达。然而，考虑到PPAR和焦虑行为之间可能的连接很少。我们审查了PPAR和焦虑之间的可能连接。我们使用了路径工作室软件（elestwier）。根据先前开发的算法创建了信号途径。Snea在路径工作室进行。 Current study revealed 14 PPAR-regulated proteins linked to anxiety. Possible mechanism of PPAR involvement in neuroinflammation protection is proposed. Signal pathway reconstruction and reviewing aimed to reveal possible connection between PPARG and CCK-ergic system was conducted. Said analysis revealed that PPARG-dependent regulation of MME and ACE peptidase expression may affect levels of nonhydrolysed, i.e., active CCK-4. Impairments in PPARG regulation and following MME and ACE peptidase expression impairments in amygdala may be the possible mechanism leading to pathological anxiety development, with brain CCK-4 accumulation being a key link. Literature data analysis and signal pathway reconstruction and reviewing revealed two possible mechanisms of peroxisome proliferator-activated receptors involvement in pathological anxiety: (1) cytokine expression and neuroinflammation mechanism and (2) regulation of peptidases targeted to anxiety-associated neuropeptides, primarily CCK-4, mechanism. SN - 1687-4757 UR - https://doi.org/10.1155/2020/8859017 DO - 10.1155/2020/8859017 JF - PPAR Research PB - Hindawi KW - ER -