TY - JOUR A2 - Cao, Hongbao AU - Lian, Meng AU - Chen, Jiaming AU - Shen, Xixi AU - Hou, Lizhen AU - Fang, Jugao PY - 2020 DA - 2020/04/22 TI -Ppargmay Promote Chemosensitivity of Hypopharyngeal Squamous Cell Carcinoma SP - 6452182 VL - 2020 AB - The upregulation of peroxisome proliferator-activated receptor gamma ( PPARG) has been shown to increase the chemosensitivity of several human cancers. This study is aimed at studying if PPARGsensitizes hypopharyngeal squamous cell carcinoma (HSCC) in chemotherapeutic treatments and at dissecting possible mechanisms of observed effects. We integrated large-scale literature data and HSCC gene expression data to identify regulatory pathways that link PPARGand chemosensitivity in HSCC. Expression levels of molecules within the PPARGregulatory pathways were compared in 21 patients that underwent chemotherapy for primary HSCC, including 12 chemotherapy-sensitive patients (CSP) and 9 chemotherapy-nonsensitive patients (CNSP). In the CPS group, expression levels of PPARG在CNSP高于集团( log ‐ fold ‐ change = 0.50 ). Structured text mining identified two chemosensitivity-related regulatory pathways driven by PPARG. In the CSP group, expression levels for 7 chemosensitivity-promoting genes were increased, while for 13 chemosensitivity suppressing the gene expression levels were decreased. Our results support the chemosensitivity-promoting role of PPARGin HSCC tumor cells, most likely by affecting both cell proliferation and cell motility pathways. SN - 1687-4757 UR - https://doi.org/10.1155/2020/6452182 DO - 10.1155/2020/6452182 JF - PPAR Research PB - Hindawi KW - ER -