TY - Jour A2 - Tan Zen Zhing Au - Wang，Jing Au - Cao，Ruihua Au - Huang，Tao Au - Liu，Cheng Au-Fan，Yidong Py - 2020 da - 2020/11/28 Ti - 尿路功能障碍相关with Nigrostriatal Dopaminergic Degeneration in Early and Untreated Patients with Parkinson’s Disease SP - 4981647 VL - 2020 AB - The aim of the present study was to determine the relation between urinary dysfunction and nigrostriatal dopaminergic degeneration in early and untreated Parkinson’s disease (PD). The data were obtained from Parkinson’s Progression Markers Initiative database. Two hundred and seventy-five patients and 149 healthy controls were included in our analysis. Urinary symptoms were evaluated with the Scale for Outcomes in Parkinson’s Disease for Autonomic Symptoms (SCOPA-AUT). We performed correlation analyses between^123.PD和健康对照患者患有尿路症状的I-FP-CIT SPECT成像数据和严重程度。与健康对照相比，早期和未经治疗的PD患者表现出较差的泌尿症状。泌尿症状的严重程度与尾部和腐肉中的多巴胺转运蛋白结合水平显着相关。控制年龄和性行为后，储存症状的严重程度与腐败的较小侧面的多巴胺转运蛋白结合水平显着相关（ R. = −0.172, P. = 0.004 ）。在两个男性中观察到相关性（ R. = −0.152, P. = 0.043 ）和女性患者（ R. = −0.217, P. = 0.034 ）。在雄性或女性患者的多巴胺转运蛋白转运蛋白结合水平和排尿症状中没有发现相关性，或健康对照中的任何尿症状。更糟糕的储存症状反映了早期和未经处理的PD的更大的纽粒子多巴胺能损失。SN - 2090-8083 UR - https：//doi.org/10.1155/2020/4981647 do - 10.1155 / 2020/4981647 jf - 帕金森病pb - hindawikw - er -