TY - Jour A2 - 郑，镇奥卢，中溪奥 - 郭，永明Au - 龚，云南澳大利亚，文余斗，鲍曼·鲍 - 李，宁岑坳王，申君奥 - 徐，袁欧 -刘，阳阳奥·陈，博互惠，易奥徐，志法，志法，Xiaowei py - 2021Da - 2021/01/18 - 2021/01/18 Ti - 神经气囊串扰和突触塑性介导的中央敏化在针灸镇痛中的作用SP - 8881557 VL - 2021 AB - 虽然疼痛被视为全球公共卫生优先权，镇痛治疗仍然是一个重大挑战。疼痛是由周边和中央致敏引起的超敏反应，后者被认为是慢性疼痛的罪魁祸首。本研究总结了神经眼压串扰和突触塑性的视角下的中央致敏的发病机制，并强调针灸相关镇痛机制。中枢致敏由升递兴奋性途径和下降疼痛调节系统中的神经递质和神经肽调节。针灸镇痛与下调兴奋性途径中的谷氨酸蛋白和上调阿片类化合物， - 氨基丁酸，去甲肾上腺素和5-羟基对羟基胺在下降疼痛调节系统中的下调相关。此外，越来越理解的是，神经递质，细胞因子和趋化因子涉及神经眼压串扰和相关的可塑性，从而有助于中央敏感性。针灸通过抑制细胞因子，例如白细胞介素-1产生镇痛作用 β，白细胞介素-6和肿瘤坏死因子 - α.，上调白细胞介素-10，以及调节趋化因子及其受体，如CX3Cl1 / CX3CR1，CXCL12 / CXCR4，CCL2 / CCL2 / CCL2和CXCL1 / CXCR2。These factors are regulated by acupuncture through the activation of multiple signaling pathways, including mitogen-activated protein kinase signaling (e.g., the p38, extracellular signal-regulated kinases, and c-Jun-N-terminal kinase pathways), which contribute to the activation of nociceptive neurons. However, the responses of chemokines to acupuncture vary among the types of pain models, acupuncture methods, and stimulation parameters. Thus, the exact mechanisms require future clarification. Taken together, inhibition of central sensitization modulated by neuroglial plasticity is central in acupuncture analgesia, providing a novel insight for the clinical application of acupuncture analgesia. SN - 2090-5904 UR - https://doi.org/10.1155/2021/8881557 DO - 10.1155/2021/8881557 JF - Neural Plasticity PB - Hindawi KW - ER -