TY - JOUR A2 - Lebwohl，M. AU - 马丁内斯，丹尼尔R. AU - 理查兹，亨特W. AU - 林，求是AU - 托雷斯 - 卡巴拉，卡洛斯A. AU - 普列托，胜者G. AU - 库里，乔纳森大号。AU - Medrano, Estela E. PY - 2012 DA - 2012/11/25 TI - H3K79me3T80ph is a Novel Histone Dual Modification and a Mitotic Indicator in Melanoma SP - 823534 VL - 2012 AB - The current study characterizes the mitosis-associated histone dual modification on the core of histone H3: trimethylation of histone H3 lysine 79 and simultaneous phosphorylation of H3 threonine 80 (H3K79me3T80ph). Through the use of protein and microscopy-based techniques, we find that H3K79me3T80ph shares a similar spatial and temporal regulation as H3S10ph but additionally requires methyltransferase activity. In addition, we find that Aurora kinase activity is necessary for the catalysis of H3K79me3T80ph 体内。最后，我们的使用组织微阵列H3K79me3T80ph的分析表明，H3K79me3T80ph马克原发性皮肤黑素瘤的具有转移潜力指示H3K79me3T80ph可以识别与更积极的临床行为侵入性黑素瘤的一个子集的子集。SN - 二○九○年至2905年UR - https://doi.org/10.1155/2012/823534 DO - 10.1155 /八十二万三千五百三十四分之二千○一十二JF - 中华皮肤癌PB - Hindawi出版公司公司KW - ER -