TY - JOUR A2 - Verma, Ajit K. AU - Sonavane, Kunal AU - Phillips, Jeffrey AU - Ekshyyan, Oleksandr AU - Moore-Medlin, Tara AU - Roberts Gill, Jennifer AU - Rong, Xiaohua AU - Lakshmaiah, Raghunatha Reddy AU - Abreo, Fleurette AU - Boudreaux, Douglas AU - Clifford, John L. AU - Nathan, Cherie-Ann O. PY - 2012 DA - 2012/12/13 TI - Topical Curcumin-Based Cream Is Equivalent to Dietary Curcumin in a Skin Cancer Model SP - 147863 VL - 2012 AB - Skin squamous cell carcinoma (SCC), the most common cancer in the USA, is a growing problem with the use of tanning booths causing sun-damaged skin. Antiproliferative effects of curcumin were demonstrated in an aggressive skin cancer cell line SRB12-p9 ( P < 0.05 而控制)。局部配方是effective as oral curcumin at suppressing tumor growth in a mouse skin cancer model. Curcumin at 15 mg administered by oral, topical, or combined formulation significantly reduced tumor growth compared to control ( P = 0.004 ). Inhibition of pAKT, pS6, p-4EBP1, pSTAT3, and pERK1/2 was noted in SRB12-p9 cells post-curcumin treatment compared to control ( P < 0.05 ). Inhibition of pSTAT3 and pERK1/2 was also noted in curcumin-treated groups in vivo. IHC analysis revealed human tumor specimens that expressed significantly more activated pERK ( P = 0.006 ) and pS6 ( P < 0.0001 ) than normal skin samples. This is the first study to compare topical curcumin to oral curcumin. Our data supports the use of curcumin as a chemopreventive for skin SCC where condemned skin is a significant problem. Prevention strategies offer the best hope of future health care costs in a disease that is increasing in incidence due to increased sun exposure. SN - 2090-2905 UR - https://doi.org/10.1155/2012/147863 DO - 10.1155/2012/147863 JF - Journal of Skin Cancer PB - Hindawi Publishing Corporation KW - ER -