TY - Jour A2 - Diaz Curiel，Manuel Au - Bystrytska，Maryna Au - Povoroznyuk，Vladyslav Au - Grygorieva，Nataliia Au - Karaban，Iryna Au - Karasevich，Nina Py - 2020 DA - 2020/03/25 Ti - 骨密度和2020/03/25Risk of Osteoporotic Fractures in Women with Parkinson’s Disease SP - 5027973 VL - 2020 AB - Osteoporosis and Parkinson’s disease (PD) are two important age-related diseases, which have an influence on pain, physical activity, disability, and mortality. The aim of this research was to study the parameters of bone mineral density (BMD), frequency, and 10-year probability of osteoporotic fractures (OFs) in females with Parkinson’s disease (PD). We have examined 113 postmenopausal women aged 50–74 years old which were divided into 2 groups (I, control group (CG),
N. = 53 and II, subjects with PD,
N. = 60). Bone mineral density of lumbar spine, femoral neck, distal radius, and total body were measured, and quantity and localization of vertebral deformities were performed by the vertebral fracture assessment (VFA). Ten-year probability of OFs was assessed by Ukrainian version of FRAX®. It was established that BMD of lumbar spine, femoral neck, distal radius, and total body in PD women was reliably lower compared to CG. The frequency of OFs in PD subjects was higher compared to CG (51.7 and 11.3%, respectively) with prevalence of vertebral fractures (VFs) in women with PD (52.6% among all fractures). 47.4% of the females had combined VFs: 74.2% of VFs were in thoracic part of the spine and 73.7% were wedge ones. Ten-year probability of major OFs and hip fracture were higher in PD women compared to CG with and without BMD measurements. Inclusion of PD in the FRAX calculation increased the requirement of antiosteoporotic treatment from 5 to 28% (without additional examination) and increased the need of additional BMD measurement from 50 to 68%. Anterior/posterior vertebral height ratios (Th8.-11.）通过VFA在PD雌性中测量而没有确认的椎体畸形与CG索引相比较低。总之，PD的女性具有较低的BMD指数，骨质疏松症率较高，以及未来低能量骨折的风险，应考虑到其骨质疏松症风险和临床管理的评估。SN - 2090-8059 UR - https://doi.org/10.1155/2020/5027973 do - 10.1155 / 2020/5027973 jf - 骨质疏松症pb - hindawikw - er -