TY - JOUR A2 - Vincenzi, Bruno AU - Abildgaard, Søren K. O. AU - Vorum, Henrik PY - 2013 DA - 2013/09/03 TI - Proteomics of Uveal Melanoma: A Minireview SP - 820953 VL - 2013 AB - Uveal melanoma (UM) continues to be associated with a high mortality rate of up to 50% due to metastatic spread primarily to the liver. Currently there are relatively effective treatments for the primary tumor, though the management of the metastatic disease remains inadequate. Conventional diagnostic tools have a low sensitivity for detecting metastasis, and early detection of metastatic spread would allow more treatment options that could ultimately increase survival of UM patients. Advanced proteomic methods have already helped to find potential biomarkers associated with UM pathogenesis and metastasis. In the present review we discuss the field of proteomics in relation to studies elucidating biomarkers of UM, where proteins such as S-100 β，Osteopontin（OPN）和黑素瘤抑制活性（MIA）已被证明与转移相关。SN - 1687-8450 UR - https://doi.org/10.1155/2013/820953 do - 10.1155 / 2013/820953 jf - 肿瘤学杂志 - Hindwi Publishing CorporationKW - ER -