TY - JOUR A2 - Raffoul，朱利安J. AU - Tacyildiz，Nurdan AU - Ozyoruk，DERYA AU - Ozelci Kavas，Guzin AU - Yavuz的，Gulsan AU - ÜNAL，EMEL AU - Dincaslan，邯郸AU - 阿塔莱，Semra AU - 尤卡，塔伊丰AU - Ikinciogullari，Aydan AU - Doganay，Beyza酒店AU - 奥克塔伊，Gulsah AU - Cavdar，艾汉AU - KUCUK，奥马尔PY - 2012 DA - 2012年10月16日TI - 硒的蒽环类药物心脏毒性的预防小儿with Cancer SP - 651630 VL - 2012 AB - High cumulative doses of anthracyclines (300–500 mg/m²用于儿童癌症患者的治疗）可导致心脏毒性限制此类化疗药物的临床应用价值，主要的长期不利影响。我们通过测量亲BNP水平和超声心动图（ECHO）的调查结果进行评估蒽环类药物的心脏毒性，调查一组儿童癌症患者的硒（Se）补充的潜在的保护作用。临血浆BNP水平进行测量，ECHO在67例（45名男，22名女，年龄2-18岁，平均年龄12岁）进行后，他们完成了含蒽环类化疗。血清硒水平在37名患者中测量。Eleven patients had high Pro-BNP levels and/or cardiac failure with Pro-BNP levels of 10–8,022 pg/mL (median 226.3 pg/mL; laboratory normal level is less than 120 pg/mL). Serum Se levels were low (20–129 mcg/L, median 62 mcg/L) in ten of these eleven patients. Eight of 10 patients with low Se and high Pro-BNP levels were supplemented with Se 100 mcg/day for a period of 4–33 months (median 6 months) which resulted in improvement in Pro-BNP and/or ECHO findings. These results suggest that Se supplementation may have a role in protection against anthracycline-induced cardiac toxicity. SN - 1687-8450 UR - https://doi.org/10.1155/2012/651630 DO - 10.1155/2012/651630 JF - Journal of Oncology PB - Hindawi Publishing Corporation KW - ER -