TY - JOUR A2 - Emanuelli, Tatiana AU - Crawford, M. S. AU - Mohr, A. E. AU - Sweazea, K. L. PY - 2020 DA - 2020/12/18 TI - Novel Organic Mineral Complex Prevents High-Fat Diet-Induced Changes in the Gut and Liver of Male Sprague-Dawley Rats SP - 8846401 VL - 2020 AB - Diet-induced obesity and metabolic syndrome are associated with the onset of gastrointestinal diseases, such as hepatic steatosis and gut inflammation. Prior research shows that a proprietary soil-derived organic mineral complex (OMC) prevents hyperglycemia, endotoxemia, and liver injury in rats fed a high-fat diet (HFD) for 10 weeks. The aim of this study was to further examine the effects of OMC on the liver and gastrointestinal health of these rats. Six-week-old male Sprague-Dawley rats (据italic> N据/italic> = 36) were divided into two dietary groups: Chow or HFD fed for 10 weeks. Animals were further divided (据italic> N据/italic> = 6/group) and administered 0, 0.6, or 3.0 mg/mL OMC in their drinking water. The 10-week HFD resulted in significant liver fat accumulation. Both OMC doses prevented hepatic increases in the glycation end product N据italic> ε.据/italic>- （羧甲基）赖氨酸（CML）诱导HFD（据inline-formula> P.据/mml:mi> 据据/mml:mo> 0.05据/mml:mn> ）。低剂量OMC用闭合蛋白的大鼠的小肠更高表达相关饲喂饮食（双向ANOVA，据inline-formula> P.据/mml:mi> 据据/mml:mo> 0.042据/mml:mn> ）。Linear discriminant analysis (LDA) effect size (LEfSe) indicated significant differences in fecal microbial composition of untreated HFD-fed rats in comparison to untreated Chow rats at 10 weeks (LDA score > 2.0 : 18). After 10 weeks, untreated HFD-fed rats were also more abundant in bacteria associated with obesity and metabolic disease in comparison to corresponding week 0 samples (LDA score > 2.0 : 31), 10-week untreated Chow (LDA > 2.0 : 18), or 10-week OMC-treated HFD-fed rats (0.6 mg/mL; LDA > 2.0 : 80, 3.0 mg/mL; LDA > 2.0 : 8). Low-dose OMC prevented the HFD-induced increase in the Firmicutes-to-Bacteroidetes (F/B) ratio (据inline-formula> P.据/mml:mi> 据据/mml:mo> 0.0416据/mml:mn> ）。与OMC治疗研究的动物表现出在第10周的肠道菌群没有显著的变化，尽管肠道炎症标志物没有显著通过饮食或治疗OMC改变。这些结果表明，OMC补充改善糖基化反应和修改HFD诱导的改变的肠道微生物群。SN - 2090-0724 UR - https://doi.org/10.1155/2020/8846401 DO - 10.1155 /八百八十四万六千四百○一分之二千○二十〇JF - 营养学和代谢PB - Hindawi出版KW - ER -据/body>