TY - JOUR A2 - Tian, Jie AU - Yan, Jun-bin AU - Luo, Min-min AU - Chen, Zhi-yun AU - He, Bei-hui PY - 2020 DA - 2020/12/15 TI - The Function and Role of the Th17/Treg Cell Balance in Inflammatory Bowel Disease SP - 8813558 VL - 2020 AB - Inflammatory bowel disease (IBD) is a chronic, inflammatory, and autoimmune disorder. The pathogenesis of IBD is not yet clear. Studies have shown that the imbalance between T helper 17 (Th17) and regulatory T (Treg) cells, which differentiate from CD4⁺T cells, contributes to IBD. Th17 cells promote tissue inflammation, and Treg cells suppress autoimmunity in IBD. Therefore, Th17/Treg cell balance is crucial. Some regulatory factors affecting the production and maintenance of these cells are also important for the proper regulation of the Th17/Treg balance; these factors include T cell receptor (TCR) signaling, costimulatory signals, cytokine signaling, bile acid metabolites, and the intestinal microbiota. This article focuses on our understanding of the function and role of the balance between Th17/Treg cells in IBD and these regulatory factors and their clinical significance in IBD. SN - 2314-8861 UR - https://doi.org/10.1155/2020/8813558 DO - 10.1155/2020/8813558 JF - Journal of Immunology Research PB - Hindawi KW - ER -