TY - JOUR A2 - Vendruscolo，莱昂德罗F. AU - Harshberger，艾琳AU - 吉尔森，艾米莉A. AU - 吉列，凯利AU - 斯通，茉莉花H. AU - 萨尔瓦多Amrani，莱拉AU - 巴尔德斯，格伦R. PY - 20161084235 VL - - 2016 AB - DA - 2016年11月6日TI - 乙醇寻求行为SP的κ阿片激动剂诱导恢复原状的，也不-BNI拮抗最近的工作表明，强啡肽（DYN）/κ阿片受体（KOR）系统可能是酒精的行为影响的关键调解人。本研究的目的是研究KOR拮抗剂norbinaltorphimine（NOR-BNI）的衰减复发寻求由于在与KOR选择性一致的时间点灌注KOR激动剂U50,488的注射能力为乙醇。雄性Wistar大鼠训练自我施用10％乙醇溶液中，然后作出答复被扑灭。Following extinction, rats were injected with U50,488 (0.1–10 mg/kg, i.p.) or saline and were tested for the reinstatement of ethanol seeking. Next, the ability of the nonselective opioid receptor antagonist naltrexone (0 or 3.0 mg/kg, s.c.) and nor-BNI (0 or 20.0 mg/kg, i.p.) to block U50,488-induced reinstatement was examined. Priming injections U50,488 reinstated responding on the previously ethanol-associated lever. Pretreatment with naltrexone reduced the reinstatement of ethanol-seeking behavior. nor-BNI also attenuated KOR agonist-induced reinstatement, but to a lesser extent than naltrexone, when injected 24 hours prior to injections of U50,488, a time point that is consistent with KOR selectivity. While these results suggest that activation of KORs is a key mechanism in the regulation of ethanol-seeking behavior, U50,488-induced reinstatement may not be fully selective for KORs. SN - 2090-7834 UR - https://doi.org/10.1155/2016/1084235 DO - 10.1155/2016/1084235 JF - Journal of Addiction PB - Hindawi Publishing Corporation KW - ER -