TY -的A2 -卡拉威,托德•r . AU - Al-Hilu萨阿德AU - Al-Shujairi, Wisam H PY - 2020 DA - 2020/08/24 TI -双重角色的细菌在癌:刺激和抑制SP - 4639761六世- 2020 AB -尽管结合致癌微生物由多个研究,还未确定细菌的作用没有正确阐明肿瘤的发展。在这次审查中,我们讨论细菌物种和癌症之间的联系,关注免疫反应的诱导炎症等刺激肿瘤细胞。最后,我们将描述潜在的细菌在目标肿瘤治疗策略改善治疗,减轻不良反应。癌症是一系列遗传变化,把正常细胞变成癌细胞。这些变化来自几个原因,包括吸烟、喝酒,阳光,接触化学或物理因素,最后慢性感染微生物,包括细菌。事实上,细菌感染不致癌,但最近发现细菌和癌症之间的联系是通过两种机制,第一个刺激慢性炎症和第二个产生致癌代谢物。而细菌是致癌剂,他们有一个双重角色消灭和清除肿瘤细胞。然而,传统的癌症治疗,包括化疗、放疗、手术、免疫疗法增加生存的机会,还有很多副作用的治疗,包括组织和正常细胞的高毒性,不能穿透肿瘤细胞,抵抗这些治疗的肿瘤细胞。因此,世界已经变成了另一种解决方案,即利用转基因微生物;因此,用生活的细菌靶向癌细胞是唯一的选择来克服这些挑战。 Bacterial therapies, whether used alone or combination with chemotherapy, give a positive effect to treat multiple conditions of cancer. Also, bacteria can be used as vectors for drug, gene, or therapy, and this is a great step to treat cancer. Thus, we review the mechanisms underlying the interaction of the microbiota residents with cancer. Cancer-associated bacteria differ from those in healthy human and are linked with gene-expression profile. We also discuss how live bacteria interact with tumor microenvironments to induce tumor regression through colonization and spread. Finally, we provide past and ongoing clinical trials that include bacteria targeting tumors. SN - 1687-918X UR - https://doi.org/10.1155/2020/4639761 DO - 10.1155/2020/4639761 JF - International Journal of Microbiology PB - Hindawi KW - ER -