TY - Jour A2 - Chaves-López，Clemencia Au - Tancho，Marius B. Au - Morris，Thureyah Au - Meyer，Mervin Au - Pretorius，Ashley Py - 2020 Da - 2020/04/08 Ti - 合理设计抗菌的抗菌活性P.eptides SP - 2131535 VL - 2020 AB - Many infectious diseases are still prevalent in the world’s populations since no effective treatments are available to eradicate them. The reasons may either be the antibiotic resistance towards the available therapeutic molecules or the slow rate of producing adequate therapeutic regimens to tackle the rapid growth of new infectious diseases, as well as the toxicity of current treatment regimens. Due to these reasons, there is a need to seek and develop novel therapeutic regimens to reduce the rapid scale of bacterial infections. Antimicrobial Peptides (AMPs) are components of the first line of defense for prokaryotes and eukaryotes and have a wide range of activities against Gram-negative and Gram-positive bacteria, fungi, cancer cells, and protozoa, as well as viruses. In this study, peptides which were initially identified for their HIV inhibitory activity were further screened for antibacterial activity through determination of their kinetics as well as their cytotoxicity. From the results obtained, the MICs of two AMPs (Molecule 3 and Molecule 7) were 12.5  μ.g / ml for K.肺炎（ATCC 700603）和6.25  μ.g / ml for P.。 铜绿假单胞菌（ATCC 22108）。两位安培迅速杀死了这些细菌 体外，防止细菌生长在几小时内。此外，即使在100的AMP浓度下，这两种肽的细胞毒性活性也明显低落  μ.g / ml。这些结果表明，分子3和7具有抗菌药物的巨大潜力，或者可以作为治疗抗生素抗菌的治疗方案设计中的铅化合物。SN - 1687-918X UR - HTTPS://Doi.org/10.1155/2020/2131535 Do - 10.1155 / 2020/21131535 JF - 国际微生物学杂志PB - Hindawi KW - ER -