TY - Jour A2 - Grossberg，George T. Au - Vojdani，Ari​​sto Au - Vojdani，Elroy Py - 2018Da - 2018/06/21 Ti - 淀粉样蛋白-1-42人类血清中普遍的交叉反应抗体可能有助于intareuronalDeposition of A-Beta-P-42 SP - 1672568 VL - 2018 AB - Antibodies against many neural antigens are detected in the sera of both patients with Alzheimer’s disease (AD) and some healthy individuals. Blood-brain barrier dysfunction could make it possible for brain-reactive autoantibodies to reach the brain, where they can react with amyloid ß peptide (AßP). The origin of these autoreactive antibodies in the blood is unclear. The goals of this study were as follows: (1) to examine the immune reactivity of anti-AßP-42 with 22 neuronal and other associated antigens, some of which are involved in the pathophysiology of AD; (2) to classify antibodies to these 22 different antigens into those that cross-react with AßP-42 and those that do not; (3) to determine whether these antibodies react with BBB proteins, nerve growth factors, and enteric neuronal antigens. Using monoclonal AßP-42 antibody and ELISA methodology, we found that the antibody was highly reactive with Aß protein, tau protein, presenilin, rabaptin-5, β-ngf，bdnf，mtg和肠道神经。与谷氨酸-R，S100b，aqp4，GFAP，MBP，MBP，MBP产生的相同抗体对中等反应产生了正常的反应。 α-synuclein，TTG-2和TTG-3，而不是其余的。这些抗体也从47名AD患者和47个对照中的血液样本中测量。发现IgG抗体以显着百分比的对照升高Aβ42和许多其他抗原。总的来说，对9/23测试抗原的平均OD值显着更高（ P.<0.001）在具有广告的样品中。我们确实能够将检测到的神经元抗体分类为与AßP-42交叉反应的那些的那些。我们的主要发现是，虽然这些抗体在对照的亚组中可能是无害的，但在受损害的BBBS的个体中，这些抗体与AßP-42交叉反应的抗体可以到达大脑，其中与AßP-42的交叉反应性可能有助于发病和广告的进展，也许是其他神经退行性障碍。SN - 2090-8024 UR - https://doi.org/10.1155/2018/1672568 do - 10.1155/2018 / 1672568 jf - 国际Alzheimer疾病杂志Pb - Hindawi Kw - ER -