TY - JOUR A2 - Cameli, Paolo AU - Yoon, Taejun AU - Ahn, Sung Soo AU - Yoo, Juyoung AU - Song, Jason Jungsik AU - Park, Yong-Beom AU - Lee, Sang-Won PY - 2020 DA - 2020/12/16 TI - Serum Amyloid A Is a Biomarker of Disease Activity and Health-Related Quality-of-Life in Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis SP - 8847306 VL - 2020 AB - Serum amyloid A (SAA) is one of the acute phase proteins synthesized in hepatocytes and secreted by various inflammation or infectious stimuli.测试SAA对抗核子细胞反机体相关机体(ANCA-AAV)患者的临床影响归为AAV并注册加入AAV患者未来观察群的75名病人也包括在内。临床和实验数据采集日期为验血日,SAA由ELISA工具箱测量Birmingham Vascultis活动评分和短期36项目健康评测(SF-36)。当BVAS超出中值时,我们分辨病人高BVAS值,那些低SF-36PCS或低SF-36MCS被定义为低HRQL多变逻辑回归分析估计高BVAS独立预测器相对风险使用应急表和chi平方测试分析SAA与BVAS正相关 R = 0.642 和FFS R = 0.367 SF-36物理组件汇总反向相关 R = - 0.456 心理构件汇总评分 R = - 0.394 )SAA与急相响应器ESR(ESR)大相联 R = 0.611 和CRP R = 0.629 )高BVAS患者显示SAA比低BVAS患者高得多(1317.1纳克/毫升对423.1纳克/毫升)多变后勤回归分析中,血清相册(ods比/OR0.132) SAA市 > 1173.6 纳克 / ml OR15.132独立关联高BVAS高BVAS和差HQL风险 SAA市 > 1173.6 纳克 / ml 比那些带高 SAA市 ≤ 1173.6 纳克 / ml RR3.419和1.493结果显示SAA可能是评估AAV疾病活动和HRQL的有用生物标志SN-0278-0240UR-https://doi.org/101155/208847306DO-10.1155/208847306JF-services标志PB-HindawiKW-ER