抽象性

OBJECTIVE: To assess the potential impact on the risk of life-threatening asthma of current recommendations in pharmacotherapy, which emphasize the early use of steroids and the avoidance of beta-agonist overuse.DESIGN: Nested case-control study.SETTING: Province of Saskatchewan.POPULATION STUDIED: From a cohort of 12,301 subjects dispensed 10 or more asthma medications from 1980 to 1987, 129 case patients were identified who had experienced an episode of fatal or near fatal asthma and 129 control patients matched to the cases on age, time period at risk and severity of asthma (as judged by the need for hospitalization for asthma in the preceding two years).METHODS: Two clinicians reviewed the therapy these 258 subjects had been dispensed over the prior two-year period and classified their treatment as ‘incompatible' or ‘compatible' (at least partially compatible) with current pharmacotherapeutic guide lines.除分类外,处理评价评分还应用到每个学习题目上。评分基础是使用防炎法(口服和吸入法)并定期使用支气管,以及口服cortcosteroid用于最近因攻击或哮喘从医院退院的病人。++SD平均处理评分为3.5+1.7,而控制评分为0.8+1.4,表示质量或药理处理差(P <0.001CONLUSY:1980-1987年萨斯喀彻温省致命和近Fata