TY - JOUR A2 - Peltekian, Kevork M. AU - Paredes-Echeverri, Sara AU - Rodríguez, Ayda N. AU - Cárdenas, Wilmer A. AU - Mendoza de Molano, Belén AU - González，John m . PY - 2020 DA - 2020/12/01 TI - Seroprevalence Antitransglutaminase和Antiendomysium抗体在成人哥伦比亚血库捐助者SP - 7541941六世- 2020 AB -乳糜泻(CD)是一种自身免疫引起的肠病从小麦谷蛋白的摄入,大麦和黑麦基因易感个体。全球乳糜泻患病率为1.4%。然而，大多数流行病学研究是在白种人人群中进行的;在拉丁美洲进行的研究很少。本研究的目的是确定在哥伦比亚队列中作为乳糜泻标志物的自身抗体的血清流行率。在这项横断面研究中，国家红十字血库哥伦比亚捐献者的血清样本于2017年6月至9月在哥伦比亚Bogotá收集。采用酶联免疫吸附法检测血清IgA抗组织转谷氨酰胺酶(TTG)水平。采用间接免疫荧光法检测血清IgA抗肌内膜炎(EMA)阳性血清。在供体样本中，用抗体测定反应性来确定祖先的遗传组成。 Those with two seroreactive assays were typed for HLA class II DQ2 and DQ8. In total, 228 blood donors participated in the study. Among them, 113 were females (49.56%) with an average age of 31.63 years (SD ± 12.99); males had an average of 34.71 years (SD ± 13.01). Only 3 (1.31%) donors reported chronic diarrhea and nonintentional weight loss; 11 (4.82%) had a family history of CD. For the serological assays, 11 donors (4.82%) were seroreactive to IgA anti-TTG: 3 had high reactivity and 8 had low reactivity. Of those seroreactive to IgA anti-TTG, 3 (1.32%) were also seroreactive to anti-EMA, and they were typed as HLA-DQ8 or HLA-DQ2. The baseline ancestral percentage of the seroreactive donors was higher for European and Native American than for African genes. The seroprevalence for anti-TTG and anti-EMA with the presence of HLA-DQ8 and HLA-DQ2 was 1.32%. Additionally, 4.82% donor participants were reactive only for anti-TTG. Compared with other studies, our findings suggest that Colombia has a high prevalence of CD markers. SN - 2291-2789 UR - https://doi.org/10.1155/2020/7541941 DO - 10.1155/2020/7541941 JF - Canadian Journal of Gastroenterology and Hepatology PB - Hindawi KW - ER -