TY -的A2 Hirata罗萨里奥d . c . AU -戴Weiran AU -曹国伟,肖颖AU -李,姗姗盟——周,双盟中,提供非盟-江,志远PY - 2020 DA - 2020/11/18 TI -长非编码RNA热空气作为竞争内源性RNA调节Connexin43重构在心房纤颤骗取微RNA - 613 SP - 5925342六世- 2020 AB -几项研究表明,长非编码RNA (lncRNAs) hox成绩单反义RNA(热空气)是参与一些心血管疾病通过调节基因表达作为竞争内源性RNA(龙头)。GJA1编码Cx43是一个潜在的目标基因的微rna - 613 (mir - 613)。与此同时,还有一个潜在的目标监管热空气和mir - 613之间的关系。本研究旨在调查热空气功能是否为龙头、调节Cx43表达心房纤颤(房颤)骗取mir - 613。热空气的表情,mir - 613, Cx43被发现在右心房附件45心脏瓣膜疾病患者,其中包括23名慢性房颤患者。热空气中,underexpressed HL-1细胞模型构造确认Cx43热空气的影响。然后,Cx43表达检测作证后热空气之间的相互作用和mir - 613 cotransfecting热空气和mir - 613。此外,荧光素酶检测进行验证热空气可以调节Cx43改造为龙头、骗取mir - 613。热空气和Cx43的表达显著下调在慢性房颤组。热空气调节积极HL-1 Cx43表达的细胞。热空气Cx43表达的调节效应可以显著减毒mir - 613。 Moreover, the inhibitory effect of miR-613 on the Cx43 expression could be obviously mitigated by HOTAIR. At last, luciferase assays confirmed HOTAIR functioned as a ceRNA in the Cx43 expression by sponging miR-613. Our study suggests that HOTAIR, functioning as a ceRNA by sponging miR-613, is an important contributor to Cx43 remolding in AF. SN - 1755-5914 UR - https://doi.org/10.1155/2020/5925342 DO - 10.1155/2020/5925342 JF - Cardiovascular Therapeutics PB - Hindawi KW - ER -