TY - Jour A2 - 塞缪尔A. Au - Muir，William W. Au - Del Rio，Carlos L. Au - Ueyama，Yukie Au - Youngblood，Bradley L. Au - George，Robert S. Au - Rausch，Carl W. AU - Lau, Billy S. H. AU - Hamlin, Robert L. PY - 2014 DA - 2014/10/27 TI - Dose-Dependent Hemodynamic, Biochemical, and Tissue Oxygen Effects of OC99 following Severe Oxygen Debt Produced by Hemorrhagic Shock in Dogs SP - 864237 VL - 2014 AB - We determined the dose-dependent effects of OC99, a novel, stabilized hemoglobin-based oxygen-carrier, on hemodynamics, systemic and pulmonary artery pressures, surrogates of tissue oxygen debt (arterial lactate 7.2 ± 0.1  mM/L and arterial base excess -17.9 ± 0.5  mM/L), and tissue oxygen tension (tPO₂）从出血休克的受控严重氧气债务的狗模型中。OC99的剂量/速率是从六只流血犬进行的试点研究建立。随后将二十四只狗随机分配给四组中的一个（ N = 6. 每组）和施用：0.0，0.065,0.325或0.65g / kg OC99结合10ml / kg乳蛋白溶液，与20ml / kg Hextend IV一起施用，超过60分钟。施用0.325g / kg和0.65g / kg OC99产生的血浆血红蛋白浓度 0.63 ± 0.01 和 1.11 ± 0.02  g/dL, respectively, improved systemic hemodynamics, enhanced tPO₂，并恢复乳酸和基础过量值与0.0和0.065g / kg OC99相比。施用0.65g / kg OC99显着升高了肺动脉压力。血浆血红蛋白浓度OC99的浓度为0.3-1.1g / dl，与胶体基流体复苏结合，组织氧气债务的标准化临床替代，改进的TPO₂，避免临床相关的肺动脉压力增加。SN - 2090-1305 UR - https://doi.org/10.1155/2014/864237 Do - 10.1155/2014 / 864237 JF - 关键护理研究和实践PB - Hindwi Publishing Corporation KW - ER -