TY - JOUR A2 - Lin, Muh-Shi AU - Yu, Ying Hao AU - Ou, Chen Yin AU - Shyu, Bai Chuang AU - Huang，安德鲁池玉兰魏PY - 2020 DA - 2020/11/25 TI -基底外侧杏仁核但不是内侧前额叶皮质会导致慢性氟西汀治疗PTSD症状小鼠SP - 8875087六世- 2020 AB -做慢性氟西汀治疗减少footshock-induced创伤后应激障碍(PTSD)的症状,包括恐惧和共病抑郁,在情境提醒阶段?此外，内侧前额叶皮层(mPFC)的亚区，包括扣带皮层1 (Cg1)、前边缘皮层(PrL)、边缘下皮层(IL)和基底外侧杏仁核(BLA)，是否参与了氟西汀对PTSD症状的改善?本研究讨论了这两个关键问题。所有小鼠均注射慢性氟西汀或生理盐水处理，适应(14天)、足震恐惧条件反射(1天)和情境提醒(3天)阶段。适应后，小鼠分别接受足电击(2 mA, 10秒)或非足电击，并在足电击箱中停留2分钟进行恐惧调节。在情境提醒阶段，他们被放置在足电击箱中2分钟。在情境提醒期的最后阶段，进行强迫游泳试验(FST)和免疫组化染色。结果显示足电击诱发恐惧和共病性抑郁。 Meanwhile, chronic fluoxetine treatments reduced fear and depression behaviors. The Cg1, PrL, IL, and BLA were seemingly to increase c-Fos expression after footshock-induced PTSD symptoms in the situational reminder phase. The fluoxetine treatments reduced only the BLA’s c-Fos expression. The findings suggest that BLA contributes to the fluoxetine amelioration of PTSD symptoms; however, the mPFC, including the Cg1, PrL, and IL, did not mediate PTSD symptoms’ amelioration stemming from fluoxetine. The present data might help us to further understand the neural mechanism of fluoxetine treatments in PTSD symptoms. SN - 0953-4180 UR - https://doi.org/10.1155/2020/8875087 DO - 10.1155/2020/8875087 JF - Behavioural Neurology PB - Hindawi KW - ER -