TY - JOUR A2 - Szok，迪莉娅AU - 帕尔，恩德雷AU - 富洛普，克里斯蒂娜·AU - 托特，PETER AU - 德利，加布里埃拉AU - 方德，佐尔坦AU - Janszky，的JózsefAU - Komoly，萨穆埃尔PY - 2020 DA - 2020 /01/02 TI - 小纤维神经病：临床病理相关性SP - 8796519 VL - 2020 AB - 小纤维神经病的发展，由于外周神经的细纤维的选择性破坏。许多常见疾病可导致这种情况，包括糖尿病，感染，自身免疫和内分泌失调，但它可能是由于遗传改变，也是如此。八十五的皮肤活检证实的小纤维神经病病例进行分析。四十一（48％）例特发性;among secondary types, hypothyreosis (9.4%), diabetes mellitus (7%), cryoglobulinemia (7%), monoclonal gammopathy with unproved significance (4.7%), Sjögren’s disease (3%), and paraneoplastic neuropathy (3%) were the most common causes. Two-thirds (68%) of the patients were female, and the secondary type started 8 years later than the idiopathic one. In a vast majority of the cases (85%), the distribution followed a length-dependent pattern. Intraepidermal fiber density was comparable in idiopathic and secondary forms. Of note, we found significantly more severe pathology in men and in diabetes. Weak correlation was found between patient-reported measures and pathology, as well as with neuropathic pain-related scores. Our study confirmed the significance of small fiber damage-caused neuropathic symptoms in many clinical conditions, the gender differences in clinical settings, and pathological alterations, as well as the presence of severe small fiber pathology in diabetes mellitus, one of the most common causes of peripheral neuropathy. SN - 0953-4180 UR - https://doi.org/10.1155/2020/8796519 DO - 10.1155/2020/8796519 JF - Behavioural Neurology PB - Hindawi KW - ER -