TY - Jour A2 - Biagini，Giuseppe Au - 王，袁奥王，强奥 - 仁，博互惠，婷奥 - 羌，景奥 - 曹，慧芳族，玉杰奥 - 刘，ZHIBIN AU -高，新安奥朱，Bing PY - 2020 DA - 2020 / 01/02 TI - “嗅觉三针”增强了SAMP8 MICE SP - 2893289 VL - 2020 AB中的空间学习和记忆能力 - 作为最重要的疗法之一in complementary and alternative medicine, acupuncture has been used in the treatment of Alzheimer’s disease (AD). Acupuncture of “olfactory three-needle” manipulation can improve the cognitive ability of AD patients. However, the mechanism of “olfactory three-needle” in AD remains largely unknown. Here, we identified that the “olfactory three-needle” therapy and eugenol olfactory stimulation both reduced the deposition of β- amyloid（A. β）蛋白质和增加突触蛋白（SYP）的表达，但只有“嗅觉三针”增强了SAMP8的空间学习和记忆能力。值得注意的是，“嗅觉三针”抑制了P38Mapk的磷酸化和海马中微胶质细胞（Mg）的过度激活。我们的研究表明，“嗅觉三针”通过抑制P38MAPK的磷酸化和MG的过度激活来增强空间学习和记忆能力，以减少神经炎症反应和神经毒性 β并促进突触再生，但与嗅觉系统的刺激并不完全一致。SN - 0953-4180 UR - https://doi.org/10.1155/2020/2893289 do - 10.1155 / 2020/2101155 / 2020/2893289 JF - 行为神经病学PB - Hindawi Kw - ER -