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J.A.Nunn，J.A. Gray，H. Hodges那 “神经毒性背部CA1病变与4 vo缺血性病变：行为比较“，行为神经病学那 卷。11.那 文章ID.603123那 10. 页面那 1999年。 https://doi.org/10.1155/1999/603123
神经毒性背部CA1病变与4 vo缺血性病变：行为比较
抽象的
暂时性脑缺血的常见后果是瞬间脑缺血的常见后果归因于海马CA1子场中的细胞损失。然而，在海马CA1之外的变量，也可以在缺血后发生。We compared the functional consequences of ischaemia and ibotenate acid CA1 lesions on 2 spatial memory tasks (water maze ‘place’ and ‘matching-to-position’) to address the possibility that extra-CA1 loss contributes to ischaemia-induced memory deficits in the rat. During place task acquisition, ischaemic rats showed deficits on more measures than ibotenic rats, and during a 1 min probe trial, only ischaemic rats were impaired. On the matching-to-position task, ibotenic rats showed greater impairment than ischaemic rats in terms of one-trial learning, whereas ischaemic rats were more impaired after Trial 2. Ischaemia and ibotenic acid lesions resulted in equivalent CA1 loss, but silver impregnation revealed additional extra-CA1 cell loss in ischaemic rats. Together with the greater behavioural deficits of ischaemic rats, these data indicate a role for extra-CA1 cell loss in ischaemia-induced memory impairments in both animals and humans.
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