TY - JOUR A2 - Al Attar, Atef M. AU - Song, Lijuan AU - Srilakshmi, Mudduluri AU - Wu, Yi AU - Saleem, T. S. Mohamed PY - 2020 DA - 2020/12/21 TI - Sulforaphane Attenuates Isoproterenol-Induced Myocardial Injury in Mice SP - 3610285 VL - 2020 AB - The development of isoproterenol- (ISO-) induced oxidative stress in the myocardium results in myocardial necrosis. Sulforaphane (SFN-0.4% of sulforaphane from standardized broccoli sprout extract) possesses chemoprotective, antidiabetic, and antibacterial activities and is also active against cardiovascular-related problems due to its antioxidant properties. This study was designed to investigate the cardioprotective effect of SFN against isoproterenol-induced myocardial injury in mice. Healthy male Swiss albino mice weighing 20–30 g were used in this study. These mice were randomly divided into five groups ( N = 6. ）。实验组中的所有小鼠在连续2天内接受异丙肾上腺素（5mg / kg bw，通过I.p.）。用SFN（4mg / kg bw）处理小鼠和 α.-Tocopherol（TCF）（TCF）（10mg / kg bw），口服饲养，分别为预防性和治疗组的预处理和后处理1-7天。在第10天，研究了以下参数：心脏重量与体重比，抗氧化参数和心脏标志物;估计线粒体酶的线粒体酶。小鼠异丙醇的给药显示血清心脏标志物和心脏线粒体ATP酶水平增加。心肌硫氨基甲酸乙酸反应物质和内源性抗氧化酶降低的增加表明，氧化应激在心肌中的异丙肾上腺素诱导。小鼠SFN的给药恢复了所有生化参数的水平，以接近正常水平。组织病理学研究进一步证实了亚磺素的保护作用。该研究得出结论，使用SFN的处理促进了内源性抗氧化活性并防止异丙酚诱导的心肌损伤。SN - 2314-6133 UR - https://doi.org/10.1155/2020/3610285 do - 10.1155 / 2020/3610285 jf - 生物研究国际pb - hindawi kw - er -