TY - JOUR A2 - Patrignani，P. AU - 的Wego，马里乌斯·特雷索尔AU - Poualeu Kamani，西尔维亚娜劳雷AU - Miaffo，大卫AU - Nchouwet，莫伊兹Legentil AU - Kamanyi，区瑞强 - Wansi Ngnokam，西尔维LEA PY - 2019 DA -2019年8月27日TI - 水提物的保护作用Baillonella toxisperma大鼠SP茎皮上地塞米松诱导的胰岛素抵抗 - 8075163 VL - 2019 AB - 本研究的目的是评估的水提取物的效果 Baillonella toxisperma茎皮对大鼠地塞米松诱导的胰岛素抵抗。定量植物化学研究上的水萃取液进行 Baillonella toxisperma总酚，类黄酮，黄酮醇及测定。Insulin resistance was induced by intraperitoneal injection of dexamethasone (1 mg/kg) for 8 days, one hour before oral administration of different treatments (extract at doses of 60, 120, and 240 mg/kg and metformin at 40 mg/kg). During the test, body weight and blood glucose level were evaluated on days 1 and 8. At the last day of treatment, the glucose tolerance test was performed in rats; after that, blood samples were collected for triglycerides, total cholesterol, LDL and HDL cholesterols, transaminases (ALT and AST), and total protein level determination. Organs (heart, liver, pancreas, and kidneys) were also collected for the relative organ weight determination. The results showed that the aqueous extract of B. toxisperma含有丰富的总酚，黄酮类，黄酮醇类和。这种提取物显著逆转大鼠地塞米松代谢改变（血脂，蛋白水平和转氨酶活性）。At doses of 120 and 60 mg/kg, Baillonella toxisperma也显著降低（ p < 0.05 ; p < 0.01 ）餐后高血糖的胰岛素抵抗大鼠。结果表明， Baillonella toxisperma可以管理胰岛素抵抗和可以是用于2型糖尿病的治疗是有用的。SN - 2633-4682 UR - https://doi.org/10.1155/2019/8075163 DO - 10.1155 /八百○七万五千一百六十三分之二千○一十九JF - 药理科学PB进展 - Hindawi出版KW - ER -