TY - Jour A2 - Olivier，Berend Au - Enogieru，Adaze Bijou Au - Omoruyi，Sylvester Ifeanyi Au - Hiss，Donavon Charles Au - Ekpo，Okobi Eko Py - 2019 DA - 2019/03/05 TI - GRP78 / BIP / HSPA5a Therapeutic Target in Models of Parkinson’s Disease: A Mini Review SP - 2706783 VL - 2019 AB - Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by selective loss of dopamine neurons in the substantia nigra pars compacta of the midbrain. Reports from postmortem studies in the human PD brain, and experimental PD models reveal that endoplasmic reticulum (ER) stress is implicated in the pathogenesis of PD. In times of stress, the unfolded or misfolded proteins overload the folding capacity of the ER to induce a condition generally known as ER stress. During ER stress, cells activate the unfolded protein response (UPR) to handle increasing amounts of abnormal proteins, and recent evidence has demonstrated the activation of the ER chaperone GRP78/BiP (78 kDa glucose-regulated protein/binding immunoglobulin protein), which is important for proper folding of newly synthesized and partly folded proteins to maintain protein homeostasis. Although the activation of this protein is essential for the initiation of the UPR in PD, there are inconsistent reports on its expression in various PD models. Consequently, this review article aims to summarize current knowledge on neuroprotective agents targeting the expression of GRP78/BiP in the regulation of ER stress in experimental PD models. SN - 2633-4682 UR - https://doi.org/10.1155/2019/2706783 DO - 10.1155/2019/2706783 JF - Advances in Pharmacological Sciences PB - Hindawi KW - ER -