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R)-3.9 (i)3 (s)4 (k o)12 (f exp)-9 (os)5.1 (ur)13 (e i)3 (s hig)-6.9 (h)4 (er in h)4 (o)11 (u)3.1 (s)-8 (e)4 (h)4.1 (o)7 (ld co)12 (n)19 (t)-5.9 (ac)-7 (t t)-6 (h)3.1 (a)9 (n m)4.1 (em)10 (b)-8.9 (er)6 (s o)12 (f t)-6 (h)4 (e g)8 (en)4 (era)-5 (l p)-9 (o)11 (p)11.1 (u)-5 (l)-3 (a)19.1 (t)-5 (io)12.1 (n.)-1 ( )]TJ /T1_0 1 Tf 0 Tc 0 Tw 9 0 0 9 86.25 335.2983 Tm [(O)-4 (b)10 (je)6 (c)-4 (t)9 (i)15 (v)4 (e.)]TJ /T1_2 1 Tf -0.022 Tw [( \037)4 (e )0.5 (a)9 (im o)12 (f )0.5 (t)-6 (hi)3 (s )0.5 (s)5 (t)10 (ud)6.9 (y )0.5 (wa)3 (s )0.5 (t)6 (o a)3 (s)5 (s)-8 (es)5 (s )0.5 (t)-6 (h)4 (e )0.5 (p)12 (r)13 (e)-8 (va)-5 (len)4 (ce )0.5 (a)9 (n)4 (d a)3 (s)5 (s)-8 (o)-8.9 (ci)-3 (a)19 (t)6 (e)-5 (d )0.5 (fac)-7 (t)6 (o)12 (r)6 (s )0.5 (o)12 (f t)10 (u)4 (b)-9 (er)13.1 (c)-7 (u)-5 (losi)3 (s )0.5 (a)9 (m)4 (o)12 (n)8 (g )0.5 (ad)11.9 (u)-4.9 (l)12 (t h)4 (o)11 (u)3 (s)-8 (e)4 (h)4 (o)7 (ld )0.5 (co)12 (n)19 (t)-6 (ac)-7 (ts )]TJ 0.017 Tw 0 -1.167 TD [(o)12 (f )0.5 (sm)4 (e)-6 (a)9 (r )0.5 (p)-9 (osi)12 (t)-5 (i)7.1 (v)8 (e p)11 (u)-5 (lm)4.1 (o)12 (n)3 (a)9 (r)-29 (y t)10 (u)4.1 (b)-9 (er)13 (c)-7 (u)-5 (losi)3.1 (s in )0.5 (H)24 (a)9 (ra)9 (m)3 (a)18 (ya )0.5 (di)3 (s)5 (t)-5 (r)-6 (ic)-7 (t, )0.5 (Or)13 (o)12 (mi)-2.9 (a R)-3 (eg)-4.9 (io)12 (n, )0.5 (E)-13 (a)3 (s)5 (t)6 (er)-6 (n )0.5 (E)22 (t)-6 (hio)11 (p)12 (i)-3 (a )0.5 (f)-10 (r)13 (o)12 (m )0.5 (F)19 (e)3 (b)12 (r)-10 (u)-3 (a)9 (r)-29 (y t)6 (o )0.5 (M)17 (a)9 (r)13 (c)6 (h, )0.5 (2019. )] endstream endobj %-------------------------------------------------------------------------------------------------- 412 0 obj % PdfSharp.Pdf.Advanced.PdfContent << /Length 2693 >> stream TJ /T1_0 1 Tf -0.007 Tc 0.007 Tw T* [(M)23 (et)2 (ho)-3 (d)-7 (.)]TJ /T1_2 1 Tf 0 Tc 0.078 Tw 3.25 0 Td [( )0.5 (A )0.5 (co)12 (mm)19.1 (uni)12 (t)-3 (y )0.5 (b)-5 (a)3 (s)-8 (e)-5 (d )0.5 (cr)13 (os)5 (s-s)-7.9 (e)-5 (c)-7 (t)-5 (io)12.1 (n)2.9 (a)-4.9 (l )0.5 (s)5 (t)10 (ud)7 (y )0.5 (desig)-5 (n )0.5 (wa)3 (s )0.5 (co)12.1 (n)3.9 (d)12 (uc)-6.9 (t)6 (e)-5 (d)6 (. )0.5 (A )0.5 (t)6 (o)11 (t)-6 (a)-5 (l )0.5 (o)12 (f )0.6 (454 )0.5 (s)5 (t)10 (ud)7 (y )0.5 (p)-5 (a)9 (r)-10 (t)-5 (ici)12 (p)-4.9 (a)9 (n)19 (ts )0.5 (w)8 (er)13 (e )0.5 (s)-8 (e)4 (le)-4.9 (c)-7 (t)6 (e)-5 (d )0.5 (u)3 (sin)8 (g )]TJ 0.082 Tw -3.25 -1.167 Td [(sys)5 (t)6 (em)3 (a)19 (t)-5 (ic s)-6 (a)9 (m)19 (p)7 (lin)8 (g m)4 (et)-5.9 (h)3.9 (o)-8.9 (d f)-10 (r)13 (o)12 (m a)-5 (l)-5 (l ad)12 (u)-5 (l)12 (t h)4 (o)11 (u)3 (s)-8 (e)4 (h)4.1 (o)6.9 (ld co)12 (n)19 (t)-6 (ac)-7 (ts o)12 (f sm)4 (e)-5.9 (a)8.9 (r p)-9 (osi)12 (t)-5 (i)7 (v)8 (e p)11 (u)-5 (lm)4.1 (o)12 (n)3 (a)8.9 (r)-28.9 (y t)10 (u)4 (b)-9 (er)13 (c)-7 (u)-5 (losi)3 (s p)-5 (a)19 (t)-5 (ien)19 (ts t)-5 (r)13 (e)-6 (a)19 (t)6 (e)-5 (d f)-10 (r)13 (o)12 (m )]TJ 0.002 Tw T* [(J)32 (u)-5 (l)7 (y )0.5 (2017 )0.5 (t)6 (o )0.5 (D)-5.9 (e)-5 (cem)10 (b)-9 (er )0.6 (2018. )0.5 (D)-6 (a)19 (t)-6 (a )0.5 (w)8 (er)13 (e )0.5 (co)7 (l)-5 (le)-4.9 (c)-7 (t)6 (e)-5 (d )0.5 (u)3 (sin)8 (g )0.6 (a )0.5 (p)12 (r)13 (et)6 (es)5 (t)6 (e)-5 (d )0.5 (a)9 (n)4 (d )0.5 (s)5 (t)-5 (r)-10 (uc)-7 (t)10 (ur)13 (e)-5 (d )0.5 (q)10 (ues)5 (t)-5 (io)12 (nn)3 (a)8.9 (ir)13 (e; )0.5 (a)9 (n)3.9 (d )0.6 (l)-3 (a)8 (b)-9 (o)12 (ra)19 (t)6 (o)12 (r)-29 (y )0.5 (exa)9 (min)3 (a)19 (t)-5 (io)12 (n )0.5 (wa)3 (s )]TJ 0.09 Tw T* [(p)12 (r)13 (o)-9 (ces)5.1 (s)-8 (e)-5 (d u)2.9 (sin)8.1 (g \035)12 (uo)12 (r)13 (es)-7.9 (cen)19 (t sm)4 (e)-6 (a)9 (r micr)13 (os)-8 (co)11 (p)-8.9 (e)6 (. L)-9 (og)-4.9 (i)3 (s)5 (t)-5 (ic r)13 (eg)-5 (r)13 (es)5 (sio)12 (n a)9 (n)3 (a)-5 (l)7 (ysi)3 (s wa)3 (s u)3 (s)-8 (e)-4.9 (d t)6 (o iden)19 (t)-5 (if)-17 (y t)-6 (h)4 (e fac)-7 (t)6 (o)12 (r)6 (s a)3 (s)5 (s)-8 (o)-9 (ci)-3 (a)19 (t)6 (e)-5 (d w)-3 (i)12 (t)-6 (h t)-5.9 (h)4 (e )]TJ 0.064 Tw T* [(inf)9 (e)-5 (c)-6.9 (t)-5 (io)12 (n o)12 (f p)11 (u)-4.9 (lm)4 (o)12 (n)3 (a)9 (r)-29 (y t)10 (u)4 (b)-9 (er)13.1 (c)-7 (u)-5 (losi)3 (s )0.5 (a)8.9 (n)4 (d )0.5 (a s)5 (t)-6 (a)19 (t)-5 (i)3 (s)5 (t)-4.9 (ic)-3 (a)-5 (l)-5 (l)7 (y )0.5 (sig)-5 (ni\034c)-3 (a)9 (n)19 (t )0.5 (a)3 (s)4.9 (s)-7.9 (o)-9 (ci)-3 (a)19 (t)-5 (io)11.9 (n )0.5 (wa)3 (s de)-5 (c)6 (l)-2.9 (a)9 (r)12.9 (e)-4.9 (d a)19 (t )]TJ ET /PlacedPDF /MC1 BDC q 425.642 272.27 5.839 6.5 re W n BT 0 g /GS1 gs /T1_3 1 Tf 0 Tw 10.0125 0 0 10.0125 425.4729 272.2694 Tm (\037)Tj ET EMC Q BT 9 0 0 9 431.482 272.2983 Tm endstream endobj %-------------------------------------------------------------------------------------------------- 413 0 obj % PdfSharp.Pdf.Advanced.PdfContent << /Length 2692 >> stream [(-va)-5 (l)12 (ue )0.5 (< 0.05. )]TJ /T1_0 1 Tf -0.014 Tc 0.014 Tw 5.78 0 Td [(R)-11 (e)-6 (s)-4 (u)-9 (lt)-10 (.)]TJ /T1_2 1 Tf 0 Tc 0.064 Tw 2.616 0 Td [( \037)4 (e )0.5 (o)15.9 (v)8.1 (era)-5 (l)-5 (l )]TJ -0.001 Tc -0.046 Tw 8.9258 0 0 9 86.25 261.7983 Tm [(p)11.9 (r)13 (e)-8.1 (va)-5.1 (len)4 (ce o)11.9 (f p)10.9 (u)-5 (lm)3.9 (o)12 (n)2.9 (a)8.9 (r)-29 (y t)9.9 (u)3.9 (b)-9 (er)13 (c)-7.1 (u)-5 (losi)3 (s a)9 (m)3.9 (o)11.9 (n)8 (g ad)11.9 (u)-5 (l)11.9 (t h)3.9 (o)10.9 (u)3 (s)-8.1 (e)4 (h)3.9 (o)6.9 (ld co)11.9 (n)19 (t)-6.1 (ac)-7 (ts wa)2.9 (s 7.8% \(95% CI: 5.8\22610.0\). \037)3.9 (e r)-6.1 (i)3 (s)3.9 (k fac)-7.1 (t)6 (o)11.9 (r)5.9 (s f)8.9 (o)12 (r t)10 (u)3.9 (b)-9 (er)13 (c)-7.1 (u)-5 (losi)3 (s)-1 ( )]TJ 0 Tc 0.036 Tw 9 0 0 9 86.25 251.2983 Tm [(inf)9 (e)-5 (c)-6.9 (t)-5 (io)12 (n a)9 (m)4 (o)12 (n)8 (g h)4 (o)11 (u)3 (s)-8 (e)4 (h)4 (o)7 (ld )0.5 (co)12 (n)19 (t)-6 (ac)-7 (ts w)8 (er)13 (e )0.5 (e)-6 (a)19 (t)-5 (in)8 (g m)4 (e)-5.9 (a)-5 (l)3 (s les)5 (s t)-6 (h)3 (a)9 (n )0.5 (t)-6 (hr)13 (e)-5 (e t)-5 (im)4 (es p)-9 (er )0.5 (d)-3 (a)18 (y \(A)28 (O)9 (R)]TJ ET BT /Span <>BDC 9 0 0 9 414.0727 251.2983 Tm ( )Tj EMC ET BT 9 0 0 9 415.164 251.2983 Tm (=)Tj ET BT /Span <>BDC 9 0 0 9 86.25 251.2983 Tm 37.126 0 Td ( )Tj EMC ET BT 9 0 0 9 421.509 251.2983 Tm (4.31; 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